SAFE PRODUCTION OF WATER FOR INJECTION ACCORDING TO GMP AND FDA RULES Water for Injection (WFI) can be produced through distillation or, also, through a downstream unit of ultrafiltration in a Reverse Osmosis system. The more safe methods are the distillation processes, such as vapor compression distillation or multiple effect distillation. Therefore, Vapor compression distillation […]
Category: Complete Lines & Plants
Purified Water (PW) & Water for Injection (WFI) – Reverse Osmosis Systems
Entirely Made in Italy, CROS sanitary Reverse Osmosis Systems are designed to produce compendial Purified Water (PW) and “cold” Water for Injection (WFI) through several water treatment steps, including Ultrafiltration (UF), according to feed water quality and production needs. Bram-Cor Water Treatment Equipment for pharmaceutical lines and plants is a wide range of cGMP systems, […]
Water for Injection – Multiple Effect Distillation systems
Every Bram-Cor SMPT – Multiple Effect Distiller is designed and manufactured according to cGMP and produced compendial Water for Injection. Each unit contains a number of boiling columns (or effects, stills) with the first column producing pure steam, which is condensed and re-distilled in the following columns decreasing the operational costs. Heating for evaporation and cooling for condensation processes are […]
Turnkey Project – Equipment Installation
Bram-Cor provides complete design, engineering, construction, installation and start-up of new pharmaceutical facilities, even assisting the Clients through scouting activities of potential Know How Licensor, transferring the Know How, providing Validation Master Plans and Standard Operating Procedures, validating, aligning industrial processes to URS and regulatory requirements. We propose reliable turnkey know-how, engineering and services about: LVP (Large Volume Parenterals) in […]
Pharmaceutical Engineering – 3D Design
This album presents some 3D design from Bram-Cor Project and Engineering team. Every process follows rigorous cGMP-compliant Standard Operative Procedures. Specification, construction, and verification steps within the lifecycle are carried out according to GAMP “V-model”. Click here to see other Bram-Cor pharmaceutical lines (water treatment, processing, filling and packaging systems). © 2022 Bram-Cor SpA
Processing – Mixing Tanks and Formulation Vessels
Bram-Cor offers a complete range of preparation lines suitable for any pharmaceutical formulation: BIOREACTORS (reactor vessels, pressure vessels), MIXING TANKS (pressure tanks, mobile mixing vessels), CUSTOMIZED FORMULATION TANKS (for high purity water mixing with powders), ATMOSPHERIC TRANSFER TANKS. The accurate finishing and the high quality of the materials used in the construction of all our equipment ensure aseptic drug […]
Pharmaceutical Water Pretreatment Systems
CUSTOMIZABLE PROJECTS ON FEED WATER EVALUATION Each BRAM-COR PRTW Water Pretreatment System is customized upon a careful evaluation of feed water quality using local water analysis. Raw water can be pre-treated to remove contaminants (such as particulates, calcium and magnesium salts, heavy metals, organics and bacteria) through different steps, including: UV lamps and control […]
Pharmaceutical Loop and User points
Bram-Cor integrates its PW-WFI-PS Generation equipment with state-of-the-art distribution loops. The Loop design is the result of a careful evaluation of Points of Use delivery criteria such as: Maximum istantaneous flow rate Pressure & temperature requirements Sanitization issues Periodic consumption requirements and duration Method of delivery […]
Pharmaceutical Conveyors and Turntables
These customized belt conveyors are designed to satisfy any requirement in the handling of pharmaceutical containers throughout the drug packaging process. Feedlines and output lines to and from production equipments can be specifically dimensioned for different container tipologies, such as glass bottles, PP bottles, small and large volume Bags. Click here to see other Bram-Cor pharmaceutical […]
Site Installation – Pickling and Passivation
Pickling and passivation processes, during the installation of a Bram-Cor Water Treatment System. Bram-Cor Water Treatment Equipment for pharmaceutical production lines: a full understanding of the drug production process is the key concept for correct design. Bram-Cor engineering focuses on fluid drugs sterile production processes, such a parenteral solutions, oral solutions, ophtalmic solutions. Bram-Cor work consists […]
