SAFE PRODUCTION OF WATER FOR INJECTION ACCORDING TO GMP AND FDA RULES Water for Injection (WFI) can be produced through distillation or, also, through a downstream unit of ultrafiltration in a Reverse Osmosis system. The more safe methods are the distillation processes, such as vapor compression distillation or multiple effect distillation. Therefore, Vapor compression distillation […]
Category: Pharmaceutical Processing
Sanitary Reverse Osmosis Systems – Purified Water and WFI Generators
Entirely Made in Italy, Bram-Cor Sanitary Reverse Osmosis Systems are designed to produce compendial Purified Water (PW, CROS Model) and “cold” Water for Injection (WFI, CROW Model) through several water treatment steps, including Ultrafiltration (UF), according to feed water quality and production needs. Bram-Cor Water Treatment Equipment for pharmaceutical lines and plants is a wide […]
Loop and User points for Pharmaceutical GMP Manufacturing
Bram-Cor integrates its PW-WFI-PS Generation equipment with state-of-the-art distribution loops. The Loop design is the result of a careful evaluation of Points of Use delivery criteria such as: Maximum istantaneous flow rate Pressure & temperature requirements Sanitization issues Periodic consumption requirements and duration Method of delivery […]
Turnkey Project for GMP Manufacturing – Equipment Installation
Bram-Cor provides complete design, engineering, construction, installation and start-up of new pharmaceutical facilities, even assisting the Clients through scouting activities of potential Know How Licensor, transferring the Know How, providing Validation Master Plans and Standard Operating Procedures, validating, aligning industrial processes to URS and regulatory requirements. We propose reliable turnkey know-how, engineering and services about: LVP (Large Volume Parenterals) in […]
Processing – Ancillary Systems for Formulation and Preparation
According to specific product requirements (viscosity, temperature, oxygen sensitivity, aseptic issues etc.), Bram-Cor integrates his formulation plants with state-of-the-art: TRANSFER PANELS – to transfer process fluids through multiple process lines TRIBLENDERS – for air-free homogeneous mixing of liquids and solids SOLUTION TRANSFER CIRCUITS – through sanitary pipelines, pumps, fittings LAMINAR FLOW CABINETS – ensuring aseptic […]
Processing – Mixing Tanks and Formulation Vessels
Bram-Cor offers a complete range of preparation lines suitable for any pharmaceutical formulation: BIOREACTORS (reactor vessels, pressure vessels), MIXING TANKS (pressure tanks, mobile mixing vessels), CUSTOMIZED FORMULATION TANKS (for high purity water mixing with powders), ATMOSPHERIC TRANSFER TANKS. The accurate finishing and the high quality of the materials used in the construction of all our equipment ensure aseptic drug […]